ChemicalBook > CAS DataBase List > JH-II-127

JH-II-127

Product Name
JH-II-127
CAS No.
1700693-08-8
Chemical Name
JH-II-127
Synonyms
JH-II-127;2-anilino-4-methylamino-5-chloropyrrolopyrimidine;2-ANILINO-4-METHYLAMINO-5-CHLOROPYRROLOPYRIMIDINE;JH-II127;JH-II 127;(4-((5-Chloro-4-(methylamino)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-3-methoxyphenyl)(morpholi;(4-((5-chloro-4-(methylamino)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-3-methoxyphenyl)(morpholino)methanone;[4-[[5-Chloro-4-(methylamino)-7H-pyrrolo[2,3-d]pyrimidin-2-yl]amino]-3-methoxyphenyl]-4-morpholinyl-methanone;[4-[[5-chloro-4-(methylamino)-7H-pyrrolo[2,3-d]pyrimidin-2-yl]amino]-3-methoxyphenyl]-morpholin-4-ylmethanone;Methanone, [4-[[5-chloro-4-(methylamino)-7H-pyrrolo[2,3-d]pyrimidin-2-yl]amino]-3-methoxyphenyl]-4-morpholinyl-;HEK293,JHII127,3T3 cells,Inhibitor,LRRK2-G2019S,Ser935,Leucine-rich repeat kinase 2,LRRK2,parkinson’s disease,inhibit,JH II 127,LRRK2-A2016T
CBNumber
CB43049255
Molecular Formula
C19H21ClN6O3
Formula Weight
416.86
MOL File
1700693-08-8.mol
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JH-II-127 Property

Melting point:
>166°C (dec.)
Density 
1.458±0.06 g/cm3(Predicted)
storage temp. 
Refrigerator
solubility 
DMSO (Slightly), Methanol (Slightly)
form 
Solid
pka
12.49±0.50(Predicted)
color 
White to Pale Beige
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SML2569
Product name
JH-II-127
Purity
≥98% (HPLC)
Packaging
5MG
Price
$123
Updated
2024/03/01
Sigma-Aldrich
Product number
SML2569
Product name
JH-II-127
Purity
≥98% (HPLC)
Packaging
25MG
Price
$396
Updated
2024/03/01
Cayman Chemical
Product number
22905
Product name
JH-II-127
Packaging
1mg
Price
$32
Updated
2024/03/01
Cayman Chemical
Product number
22905
Product name
JH-II-127
Packaging
5mg
Price
$139
Updated
2024/03/01
Cayman Chemical
Product number
22905
Product name
JH-II-127
Packaging
10mg
Price
$243
Updated
2024/03/01
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JH-II-127 Chemical Properties,Usage,Production

Description

JH-II-127 is an orally bioavailable inhibitor of wild-type (WT) and mutant forms of leucine-rich repeat kinase 2 (LRRK2). It inhibits WT LRRK2, as well as LRRK2 containing the G2019S and A2016T substitution mutations (IC50s = 6.6, 2.2, and 47.7 nM, respectively), which are present in certain patients with Parkinson’s disease, but not LRRK2 containing both mutations (IC50 = 3,080 nM). JH-II-127 (0.1-0.3 μM) inhibits phosphorylation of the serines at positions 910 and 935 of WT LRRK2 and LRRK2G2019S in vitro. It also inhibits Ser935 phosphorylation in vivo in mouse brain, spleen, and kidney when administered at a dose of 30 mg/kg.

Uses

JH-II-127 is a highly potent, selective, and brain penetrant LRRK2 inhibitor.

storage

Store at -20°C

JH-II-127 Preparation Products And Raw materials

Raw materials

Preparation Products

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JH-II-127 Suppliers

China 61 India 1 United Kingdom 1 United States 8 Global 71
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View Lastest Price from JH-II-127 manufacturers

Career Henan Chemical Co
Product
JH-II-127 1700693-08-8
Price
US $1.00/KG
Min. Order
1KG
Purity
97%-99.9%
Supply Ability
100kg
Release date
2019-12-26

1700693-08-8, JH-II-127Related Search:


  • JH-II-127
  • (4-((5-Chloro-4-(methylamino)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-3-methoxyphenyl)(morpholi
  • (4-((5-chloro-4-(methylamino)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-3-methoxyphenyl)(morpholino)methanone
  • 2-anilino-4-methylamino-5-chloropyrrolopyrimidine
  • 2-ANILINO-4-METHYLAMINO-5-CHLOROPYRROLOPYRIMIDINE;JH-II127;JH-II 127
  • [4-[[5-Chloro-4-(methylamino)-7H-pyrrolo[2,3-d]pyrimidin-2-yl]amino]-3-methoxyphenyl]-4-morpholinyl-methanone
  • Methanone, [4-[[5-chloro-4-(methylamino)-7H-pyrrolo[2,3-d]pyrimidin-2-yl]amino]-3-methoxyphenyl]-4-morpholinyl-
  • [4-[[5-chloro-4-(methylamino)-7H-pyrrolo[2,3-d]pyrimidin-2-yl]amino]-3-methoxyphenyl]-morpholin-4-ylmethanone
  • HEK293,JHII127,3T3 cells,Inhibitor,LRRK2-G2019S,Ser935,Leucine-rich repeat kinase 2,LRRK2,parkinson’s disease,inhibit,JH II 127,LRRK2-A2016T
  • 1700693-08-8